|Titel: Homocysteine and cognitive function in very elderly nondemented subjects.|
To examine the association of homocysteine with cognitive functioning in very elderly community-dwelling individuals (80 years or older).
Two hundred twenty-eight nondemented community-dwelling individuals were assessed with a broad neuropsychological battery. Bloods were drawn to measure homocysteine, serum vitamin B12, and folate levels and APOE genotype.
Higher homocysteine levels were associated with poorer executive-language functioning scores (r = -0.311). The association persisted when serum B12 and folate levels were controlled for (r = -0.308). Homocysteine levels were not associated with memory score (r = 0.120).
In very elderly, nondemented community dwellers, high homocysteine levels are associated with poorer executive-language functioning but not with memory. This possible differential effect of homocysteine on cognitive functions suggests that it may affect only specific brain regions or mechanisms underlying healthy executive functioning.
|Autoren: West Rebecca K, Beeri Michal Schnaider, Schmeidler James, Mitchell Dara B, Carlisle Katherine R, Angelo Gary, Mavris Rizalina, Langhoff Erik, Rosendorff Clive, Silverman Jeremy M|
|Publikation: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2011 Jul;19(7):673-7|
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