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Titel: A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Datum: 08-08-11
Zusammenfassung: Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5'-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (± 1 year), date (± 1 year) and time (± 3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate ≤ 5, 5-10, 10-15 (reference), 15-20, and > 20 nmol/L were 1.58 (95% CI=0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR=1.17, 95% CI=1.00-1.38) but not in women (OR=0.91, 95% CI=0.78-1.07; p for heterogeneity <0.01). Our results suggest a U-shaped association between plasma folate and pancreatic cancer risk in both men and women. The positive association that we observed between methionine and pancreatic cancer may be sex dependent and may differ by time of follow-up. However, the mechanisms behind the observed associations warrant further investigation.
Autoren: Chuang Shu-Chun, Stolzenberg-Solomon Rachael, Ueland Per Magne, Vollset Stein Emil, Midttun Øivind, Olsen Anja, Tjønneland Anne, Overvad Kim, Boutron-Ruault Marie-Christine, Morois Sophie, Clavel-Chapelon Françoise, Teucher Birgit, Kaaks Rudolf, Weikert Cornelia, Boeing Heiner, Trichopoulou Antonia, Benetou Vassiliki, Naska Androniki, Jenab Mazda, Slimani Nadia, Romieu Isabelle, Michaud Dominique S, Palli Domenico, Sieri Sabina, Panico Salvatore, Sacerdote Carlotta, Tumino Rosario, Skeie Guri, Duell Eric J, Rodriguez Laudina, Molina-Montes Esther, Huerta José Marı A, Larrañaga Nerea, Gurrea Aurelio Barricarte, Johansen Dorthe, Manjer Jonas, Ye Weimin, Sund Malin, Peeters Petra H M, Jeurnink Suzanne, Wareham Nicholas, Khaw Kay-Tee, Crowe Francesca, Riboli Elio, Bueno-de-Mesquita Bas, Vineis Paolo
Publikation: European journal of cancer (Oxford, England : 1990) 2011 Aug;47(12):1808-16
Links zum Volltext:
Elsevier Science
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Europe PubMed Central
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Hazardous Substances Data Bank
Hazardous Substances Data Bank
Hazardous Substances Data Bank
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MedlinePlus Health Information

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