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Titel: A decreased micronucleus frequency in human lymphocytes after folate and vitamin B12 intervention: a preliminary study in a Yunnan population.
Datum: 04-07-13
Zusammenfassung:

BACKGROUND

Micronucleus (MN) is a validated biomarker for DNA damage in peripheral blood lymphocytes (PBL) and is a reflection of the changes of human nutritional status. Folate (FA) and vitamin B(12) are one-carbon metabolism-related micronutrients, which play important roles in maintaining genomic stability.

OBJECTIVE

To investigate the correcting effects of FA and B(12) intervention on DNA damage in PBL.

METHOD

One hundred fifty-six volunteers without history of cancer were divided into 5 age groups (20 - 69 y, 47.4 % male) for establishing the baseline of chromosomal damage by means of cytokinesis-block micronucleus assay. Twelve individuals whose MN frequency was higher than the median value in each age group were selected for a four-month FA (200 - 400 μg/day)-B12 (3.125 - 25 μg/day) intervention dosed as to age and MTHFR genotypes.

RESULTS

There were significantly positive correlations between age and MN frequency in all groups (p < 0.01). Among all age groups, the baseline MN frequencies were higher in females than that in males. The MN frequencies from 10 volunteers were reduced by 33.5 % after the intervention with the two micronutrients (p < 0.01), and two individuals did not show any changes.

CONCLUSION

Dietary supplement intake of FA and B(12) based on MTHFR genotypes could protect the genome from damage and benefit genome health.

Autoren: Ni Juan, Liang Ziqing, Zhou Tao, Cao Neng, Xia Xiaolin, Wang Xu
Publikation: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2012 Dec;82(6):374-82
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